Selected publications
L-plastin enhances NLRP3 inflammasome assembly and bleomycin-induced lung fibrosis
March 15, 2022
Joshi H, Almgren-Bell A, Anaya EP, Todd EM, Van Dyken SJ, Seth A, McIntire KM, Singamaneni S, Sutterwala F, Morley SC. L-plastin enhances NLRP3 inflammasome assembly and bleomycin-induced lung fibrosis. Cell Rep. 2022 Mar 15;38(11):110507. doi: 10.1016/j.celrep.2022.110507. PMID: 35294888; PMCID: PMC8998782.
Novel mouse model reveals that serine phosphorylation of l-plastin is essential for effective splenic clearance of pneumococcus
May 1, 2021
Anaya EP, Lin X, Todd EM, Szasz TP, Morley SC. Novel Mouse Model Reveals That Serine Phosphorylation of L-Plastin Is Essential for Effective Splenic Clearance of Pneumococcus. J Immunol. 2021 May 1;206(9):2135-2145. doi: 10.4049/jimmunol.2000899. Epub 2021 Apr 15. PMID: 33858961; PMCID: PMC8323710.
Recovery from COVID-19 in a Child with Chronic Granulomatous Disease and T Cell Lymphopenia
October 8, 2020
Mantravadi V, Nguyen ST, Morley SC, Bednarski JJ, Kitcharoensakkul M, Cooper MA. Recovery from COVID-19 in a Child with Chronic Granulomatous Disease and T Cell Lymphopenia. J Clin Immunol. 2021 Jan;41(1):23-25. doi: 10.1007/s10875-020-00896-2. Epub 2020 Oct 27. PMID: 33108551; PMCID: PMC7588587.
miR-125a-5p regulates megakaryocyte proplatelet formation via the actin-bundling protein L-plastin
October 27, 2020
Bhatlekar S, Manne BK, Basak I, Edelstein LC, Tugolukova E, Stoller ML, Cody MJ, Morley SC, Nagalla S, Weyrich AS, Rowley JW, O’Connell RM, Rondina MT, Campbell RA, Bray PF. miR-125a-5p regulates megakaryocyte proplatelet formation via the actin-bundling protein L-plastin. Blood. 2020 Oct 8;136(15):1760-1772. doi: 10.1182/blood.2020005230. PMID: 32844999; PMCID: PMC7544541.
The Association of Medications and Vaccination with Risk of Pneumonia in Inflammatory Bowel Disease
May 12, 2020
Gregory MH, Ciorba MA, Wiitala WL, Stidham RW, Higgins P, Morley SC, Hou JK, Feagins LA, Govani SM, Cohen-Mekelburg SA, Waljee AK. The Association of Medications and Vaccination with Risk of Pneumonia in Inflammatory Bowel Disease. Inflamm Bowel Dis. 2020 May 12;26(6):919-925. doi: 10.1093/ibd/izz189. PMID: 31504531; PMCID: PMC7350553.
Neutrophil L-Plastin Controls Ocular Paucibacteriality and Susceptibility to Keratitis
April 3, 2020
Lu X, Kugadas A, Smith-Page K, Lamb J, Lin T, Ru Y, Morley SC, Fichorova R, Mittal SK, Chauhan SK, Littleton S, Saban D, Gadjeva M. Neutrophil L-Plastin Controls Ocular Paucibacteriality and Susceptibility to Keratitis. Front Immunol. 2020 Apr 3;11:547. doi: 10.3389/fimmu.2020.00547. PMID: 32318063; PMCID: PMC7147296.
L-Plastin deficiency produces increased trabecular bone due to attenuation of sealing ring formation and osteoclast dysfunction
January 22, 2020
Chellaiah MA, Moorer MC, Majumdar S, Aljohani H, Morley SC, Yingling V, Stains JP. L-Plastin deficiency produces increased trabecular bone due to attenuation of sealing ring formation and osteoclast dysfunction. Bone Res. 2020 Jan 22;8:3. doi: 10.1038/s41413-019-0079-2. PMID: 31993243; PMCID: PMC6976634.
Inhaled GM-CSF in neonatal mice provides durable protection against bacterial pneumonia
August 14, 2019
Todd EM, Ramani R, Szasz TP, Morley SC. Inhaled GM-CSF in neonatal mice provides durable protection against bacterial pneumonia. Sci Adv. 2019 Aug 14;5(8):eaax3387. doi: 10.1126/sciadv.aax3387. PMID: 31453341; PMCID: PMC6693910.
Alveolar macrophage development in mice requires L-plastin for cellular localization in alveoli
December 15, 2016
Todd EM, Zhou JY, Szasz TP, Deady LE, D’Angelo JA, Cheung MD, Kim AH, Morley SC. Alveolar macrophage development in mice requires L-plastin for cellular localization in alveoli. Blood. 2016 Dec 15;128(24):2785-2796. doi: 10.1182/blood-2016-03-705962. Epub 2016 Oct 6. PMID: 27758872; PMCID: PMC5159703.