Immune cells constantly move in various directions as they defend the host against pathogens. This movement is driven by dramatic changes in cell shape, which are induced by alterations in the actin cytoskeleton. At the Morley Lab, we are focused on understanding how these elements regulate immune cell shape and motility, and how impairments in motility can affect immune cell development and activation.
The Morley Lab studies both adaptive and innate immune responses, with current projects investigating B cells and alveolar macrophages. Our primary model system uses mice lacking an actin-binding protein called L-plastin, which is only expressed in cells of the immune system (the “L” stands for “leukocyte”). Thus far, we have identified requirements for L-plastin in cell migration and activation. We are employing various techniques to elucidate these mechanisms. Other immune cell types are also likely to have defects, making these research areas wide open for exploration. Additionally, we are working with a pneumococcal model of infection and are interested in exploring other infectious models in the future.
